SUAREZ, R.K.; DARVEAU, C.-A.; O’BRIEN, D.M.; ROUBIK, D.W.; Univ. of California, Santa Barbara; Univ. of British Columbia; Swarthmore College; Smithsonian Tropical Research Institute: Heirarchical and Metabolic Regulation in the Evolution of Metabolic Scaling The allometric scaling of metabolic rate, the evolution of flux capacities in pathways, the regulation of metabolism, and the reconciliation of mechanistic […]

BUCK, Leslie T; University of Toronto: Channel Arrest in the Anoxic Turtle Brain It has been 16 years since the channel arrest hypothesis was introduced by Peter Hochachka (1986). His realization that ATP consuming membrane functions, primarily ion movement, must be reduced in order to survive long-term anoxia initiated a search by comparative physiologists for […]

SCHULTE, P.M.; University of British Columbia, Vancouver: Changes in gene expression as adaptations to environmental change As pointed out by Hochachka and Somero in the classic book �Biochemical Adaptation�, two distinct classes of adaptive adjustments in the metabolic machinery of the cell are possible in principle: changes in quantities (expression) or changes in properties (kinetics). […]

STOREY, Kenneth B.; Carleton Univ.: Anoxia and Hypoxia: Oysters, Turtles and Beyond. A major thrust of Peter Hochachka’s work from the early 1970’s onward was how animals functioned in low oxygen environments. Peter and his students attacked problems in hypoxia and anoxia tolerance at various levels of biology. Marine invertebrates served as models for discovery […]

KARUNANITHI, Shanker; NEAL, Scott/J; BEST, Adrienne/G; WESTWOOD, J/Timothy; ATWOOD, Harold/L; Univ. of Toronto; Univ. of Toronto; Univ. of Toronto; Univ. of Toronto; Univ. of Toronto: Synaptic Adaptation to Thermal Stress In response to a prior heat shock, Drosophila glutamatergic synapses rapidly adapt to maintain function under heat stress. Heat shock protein 70 (Hsp70) was identified […]

HIGASHIJIMA, S.; MANDEL, G.; FETCHO, J. R.; SUNY Stony Brook; SUNY Stony Brook; SUNY Stony Brook: Optical and genetic studies of neuronal networks for movement II Genetic tools available for zebrafish offer many advantages for the study of neuronal circuitry. By injecting a DNA construct coding for green fluorescent protein (GFP) into one-cell stage embryos, […]

FETCHO, J.R.; HIGASHIJIMA, S.; SUNY Stony Brook; SUNY Stony Brook: Optical and genetic studies of neuronal networks for movement I Understanding the neuronal basis of behavior typically requires monitoring activity of the relevant neurons during behavior, working out the wiring diagrams of the circuits for the behavior of interest, and then perturbing the system to […]

MERRYWEST, S.D.; SILLAR, K.T.; University of St Andrews: Noradrenergic control of cell properties and synaptic transmission during motor pattern generation. In vertebrates, the amine noradrenaline (NA) can initiate, sustain and modulate rhythmic motor activity. We have examined the noradrenergic modulation of sensory inputs and resulting motor outputs in the intact CNS of Xenopus laevis tadpoles. […]

ATWOOD, Harold L.; University of Toronto: Neuromuscular Junctions and Motor Neurons of Arthropods Motor neurons of arthropods present combinations of physiological and morphological properties which endow them with unique performance abilities. Within genetically specified limits, adaptive modification of their properties can occur both during development and after maturation. Extreme differences in neuromuscular performance are found […]

SILLAR, K.T.; MERRYWEST, S.D.; MCLEAN, D.L.; University of St Andrews: Neuromodulation of developing spinal motor networks Following their initial assembly, the spinal cord networks controlling rhythmic motor behaviours are subject to neuromodulation by various descending brainstem pathways. These pathways are also involved in the maturation process that occurs in central locomotor networks after birth or […]