TALAMANTES, Frank; ORTIZ, Rudy: Structure and Regulation of Expression of The Mouse Growth Hormone Binding Protein The growth hormone binding protein (GHBP) in the mouse consists of a ligand-binding domain, which is identical to the extracellular portion of the growth hormone receptor (GHR) and a hydrophilic carboxyl terminal domain, in place of the transmembrane and […]

ROSNER, W.; HRYB, D.J.; KAHN, S.; KHAN, M.S.; NAKHLA, A.M.; ST. GEORGE, J.: Sex Hormone-binding Globulin as an Intermediate in Sex Steroid Signaling at the Cell Membrane In plasma, certain androgens and estrogens are bound to sex hormone-binding globulin (SHBG) with high affinity. SHBG not only regulates the concentration of free androgens and estrogens in […]

BREUNER, Creagh W.: Plasma Binding Proteins As Mediators Of Corticosteroid Action In Vertebrates In trying to understand how corticosteroids alter physiology and behavior we investigated properties of corticosteroid binding proteins (CBG) in the plasma of several vertebrate species. These comparative studies have led to a number of disparate but interesting findings. 1) The binding specificity […]

COHEN, P: Intracellular and Nuclear Interactions of IGFBPs Multiple IGF-independent actions of IGFBPs have been identified in recent years. These include growth-inhibition, apoptosis, and regulation of gene expression. IGFBPs interact directly with multiple extracellular molecules with known growth regulatory functions ranging from heparin to transferrin. It is yet entirely unknown how some IGFBPs enter cells, […]

MOHAN, S*; BAYLINK, D.J.: IGF Binding Proteins (IGFBPs) Are Multifunctional And Act Via IGF-Dependent and IGF-Independent Mechanisms Traditionally, binding proteins are known to regulate the activity of ligands by prolonging their half-life and IGFBPs are no exception to this. In addition to the function of IGFBPs as simple carrier proteins, IGFBPs in serum function to […]

BIER, E.; SRINIVASAN, S.: Extracellular Modulation of BMP Signaling A variety of extracellular modulators of BMP signaling act by binding to BMP ligands. Some of these factors reduce the availability of BMPs by sequestering them and preventing them from gaining access to all or specific subsets of BMP-receptors while others may promote the activities of […]

GONZALEZ-FERNANDEZ, Federico: Evolution and Functions of Retinoid-binding Proteins “RBPs”: The interphotoreceptor “IRBP” The design of the vertebrate retina took a radical departure from that of invertebrates. The involution of the optic vesicle allows photoreceptors to be closely packed and the pigmented epithelium (RPE) and photoreceptors divide the labor of biochemical processes such as the visual […]

DUAN, Cunming: EXTRACELLULAR AND NUCLEAR ACTIONS OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS Regulation of peptide growth factor/hormone activities by secreted hormone binding proteins has emerged as a common theme in cell-cell communication. Among the best studied hormone binding proteins are members of the insulin-like growth factor binding protein (IGFBP) gene family. To date, six distinct […]

SEASHOLTZ, A.F.: Corticotropin-Releasing Hormone-Binding Protein: In vivo Roles in the Pituitary and CNS Corticotropin-releasing hormone (CRH) is widely recognized as the key physiological regulator of the mammalian stress response.� Within the HPA axis, CRH is the principal hypothalamic hormone controlling pituitary ACTH synthesis and release. At other sites in the central nervous system (CNS), CRH […]

KELLEY, Kevin M.: Comparative Biology of the Insulin-like Growth Factor-binding Protein (IGFBP) Early in the chordate line, the IGF axis diverged from the insulin system and specialized in cell growth activation and allied anabolic functions. Supporting this divergence was an early presence of soluble IGFBPs which bind IGF peptides with higher affinities than that of […]