The impacts of early life exposure to the broad-spectrum antiparasitic Ivermectin on long-term growth rates, organ growth, and susceptibility to chytridiomycosis in juvenile amphibians


Meeting Abstract

27-2  Friday, Jan. 4 13:45 – 14:00  The impacts of early life exposure to the broad-spectrum antiparasitic Ivermectin on long-term growth rates, organ growth, and susceptibility to chytridiomycosis in juvenile amphibians BOWEN, V*; MCMAHON, T/A; FERNANDEZ-DENMARK, S; GRIM, J/M; University of Tampa; University of Tampa; University of Tampa; University of Tampa jgrim@ut.edu

Chytrid fungus (Batrachochytrium dendrobatidis– Bd) is decimating amphibian populations globally by disrupting organismal osmotic regulation, leading to cardiac arrest. Many laboratory studies clear amphibians of internal parasites with Ivermectin before beginning disease trials. To date, no study has considered the long-term impacts of this treatment on animal health or long-term disease susceptibility. Consequently, we tracked the effects of early life Ivermectin treatment on growth and mortality rates in Cuban tree frogs (Osteopilus septentrionalis) from ages 1-3 years, quantified organ weights, and susceptibility to Bd infection. Untreated individuals had both higher absolute weights at all time points and higher growth rates, relative to treated individuals. At the conclusion of the long-term study, Cuban tree frogs were exposed to Bd for two weeks and the spleen, liver, heart, and other tissue samples were collected and weighed. While Ivermectin dosing is an effective anti-parasitic treatment, we found that early life exposure is likely to have unintended impacts on organismal growth and health.

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