The study of ecological immunology provides a framework for investigating interactions that influence the strength and nature of animal immune responses. Costs associated with mounting immune responses presumably lead to trade-offs with other physiological processes (e.g., reproduction), but inherent to these factors is the organism’s pace of life. Two papers published in ICB, Lee (2006) and Sandmeier and Tracy (2014), present hypotheses on the ways in which vertebrate pace of life should predict immunological investment in innate vs. adaptive, and constitutive vs. induced, immune responses. Specifically, “slow-living” (long-lived, slow-growing) species are predicted to invest more in induced, adaptive immunity. Investment into these costly immune responses prioritizes survival to enable future reproduction, but also prepares the host for repeated exposure to a pathogen with immune memory enabled by the adaptive immune response. In contrast, “fast-living” (short-lived) species are quick to reproduce and are predicted to rely more on constitutive, innate (non-specific) immunity. In this study, we took a quantitative approach to testing the ecoimmunological pace of life model. With a meta-analysis of over 300 effect sizes from peer-reviewed literature of vertebrate immune responses to parasites, pathogens, and artificial stimuli, we assessed the generality of predictions surrounding life-pace and immune responses. Using longevity as a metric of pace of life, we found that immune responses follow predictions of immune investment in some taxa and not others. We use these data to address differences in immune responses between endotherms and ectotherms, as well as tropical vs. temperate species.