Color is ubiquitous in nature; however, the ability to rapidly change color in response to environmental cues is unique to few biological systems and has captured the imagination of scientists and the public for decades. Cephalopods, including squid, octopus, and cuttlefish, are one such system that can rapidly camouflage in different underwater environments by employing a sophisticated ensemble of optical organs. While these animals have been a subject of research for many years, the fundamental physics and chemistry underlying their color modulation is still not well understood and the reality of creating a material that mimics such outstanding capabilities remains elusive. A recent study of their dermal chromatophore organ revealed an abundance of lens-crystallin proteins confined within nanostructured pigment granules, indicating a functional convergence between the eyes and skin of the animals that has yet to be explored. This talk will build off this exciting finding and discuss a potential role of these proteins in facilitating signal transduction during camouflage.