HANRAHAN, J.W.* *; ZHU, T.; DAHAN, D.; FUNG, S.; MEREDITH, J.; PHILLIPS, J.E.: The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel CFTR is a phosphorylation-regulated chloride channel and member of the ATP binding cassette (ABC) transporter superfamily of proteins. There have been no reports of CFTR homologues in invertebrate animals although ABC transporters are […]

Patrick, M.L.*; Bradley, T.J.: Salt-Lovin’ Skeeters: The Osmoconforming Strategy of Mosquito Larvae Culex is a genus of mosquito that possesses both freshwater restricted (e.g. C. quinquefasciatus) and euryhaline larvae (e.g. C. tarsalis), the latter being able to tolerate up to 70% full strength seawater. While held in freshwater conditions, both the euryhaline and the freshwater-restricted […]

HARRISON, J.F.: Renal and Respiratory Mechanisms of Acid-base Regulation in Grasshoppers In 1961, J.E. Phillips first provided data to support the hypothesis that active, regulated secretion of acid by the grasshopper hindgut functions as a pH regulatory mechanism. Subsequent studies by Phillips and co-workers, and our laboratory have strongly supported this hypothesis. First, it is […]

Clark, T.M.: Integrative Aspects of Epithelial Transport in Larval Aedes aegypti In contrast to the extensively studied hormonal regulation of Malpighian tubule function, regulation of midgut transport has been largely ignored. 5-hydroxytryptamine (5-HT; serotonin) is perhaps best known among insect transport physiologists as one of a suite of hormones regulating Malpighian tubule function. In larval […]

Lewis, S.A.: Extracellular Modulation of Epithelial Permeability One of the primary functions of an epithelium is to act as a barrier to the movement of substances between the lumen of the epithelium and the blood. Loss of epithelial barrier function due to cell death can lead to a loss of homeostasis and result in death […]

SPRING, J.H.*; HAZELTON, S.R.: Excretion in the house cricket, Acheta domesticus: Effects of cAMP on membrane dynamics, cell ultrastructure and secretion. In Acheta domesticus, the Malpighian tubules (Mt) are composed of three regions, each consisting of a single cell type. The cells of the mid-tubule display the classic architecture of transport epithelia, possessing extensive basolateral […]

CHAMBERLIN, M.E.: Developmental Changes in Insect Epithelial Ion Transport and Metabolism Like other caterpillars, the tobacco hornworm (Manduca sexta) is essentially an eating machine that consumes large amounts of food to fuel the growth and development of the subsequent two developmental stages. Commensurate with its huge appetite is a large midgut, which is involved in […]

Martin, J.E.: Advances Through the Insect Hindgut How are insects able to maintain internal osmotic and ionic balance in the face of environmental challenges? Since early studies by Phillips which established desert locusts actively conserve water and produce a hyperosmotic excreta, the question of how homeostasis is achieved has been the central focus of his […]