A ubiquitous feature of phenotypes is the modular architecture of composing traits. Modularity expresses the organization of phenotypic elements into modules that comprise high integration among components that likely share developmental pathways or execute integrated functions, in contrast to a lower correlation between components of different modules. The tetrapod autopodium is an excellent system to explore modularity, as it has been deeply studied under functional, developmental and ecological approaches. In lizards, increased palmar surface area and elongated Digit IV are interpreted as important for locomotion in sand in some species of the Tropiduridae. Our hypothesis is that colonization of sandy environments by Tropiduridae lizards affected the intensity of phenotypic integration among digit elements in the autopodium. Using X-ray and imaging software, we measured the length of individual phalanges, metacarpals and metatarsals in forelimbs (manus) and hindlimbs (pes) of six species in Tropiduridae. Our morphological database comprises 17 linear measurements in manus and 19 linear measurements in pes. Results provided correlation coefficients near 0.8 comprising the digit elements in both limbs, indicating that the autopodium is highly integrated. The comparison test between empiric and theoretical matrices in Tropidurus catalanensis showed evidence for two modules in pes: one comprising proximal phalanges and metatarsal elements and another encompassing distal phalanges in all five digits. Results likely indicate functional and developmental relationships among osteological elements, justifying the use of tropidurid lizards as a model and promoting unique insights about how osteological elements are integrated throughout ontogeny.