MOMMSEN, T.P.; BUSBY, E.R.; Univ. of Victoria; Univ. of Victoria: Hormones regulating glucose metabolism: the good and the ugly (without the bad)

Even though plasma glucose in fishes may not be as tightly controlled as in mammals, numerous hormones interact to regulate piscine glucose metabolism. The presentation will review the specific metabolic roles, sites of control and mechanisms of action for selected glucoregulatory hormones. Among these hormones are cortisol, insulin-like growth factor-I and insulin – the good – and proglucagon-derived peptides (glucagon, glucagon-like peptides 1 and 2) -the ugly. In the framework of teleostean fish, specific emphasis will be on tissue, species and evolutionary variability of some peptide hormones and their receptors. In addition, the review will point out the mechanisms and sites where these hormones interface with diverse intracellular and extracellular targets that directly or indirectly affect glucose metabolism.