The snow leopard (Panthera uncia) is anatomically and physiologically adapted for life in the rocky terrain of alpine zones in Central and South Asia. P. uncia is scansorial, and typically hunts solitarily using overhead ambush of prey, rather than the typical stalking pattern of other large pantherines. In this study, we dissected, documented in detail, and imaged the limb anatomy in two adult P. uncia specimens (1M/1F). We found notable, functional differences in P. uncia limb morphology compared to other carnivorans. Enlarged scapular and pectoral musculature likely provide extra forelimb power and stability for climbing steep, icy, mountainous terrain. An unarticulated bony clavicle, greatly reduced compared to other pantherines, may provide greater flexibility to the pectoral girdle. Extra muscular heads and insertions around the elbow provide stability and power to the joint. Intrinsic muscles of the palmar manus are broad and fleshy, creating an enlarged surface area to evenly distribute body weight while walking on soft snow. Tendinous connections between the plantar digital flexors and extensors in the pes may coordinate fine pedal movements. Expanded hip adductors and extensors likely facilitate climbing and head-first descent down cliffs. The attachment sites of several key stifle flexors suggest an increased need for propulsion during running and leaping. Enlarged plantar flexors facilitate rapid, powerful ankle extension, as is required during jumping. P. uncia displays some adaptive parallels with arboreal climbing pantherines, such as the clouded leopard, while also showing adaptations for terrestrial running.