Atrazine (ATR) is one of the most commonly used herbicide in the U.S. Midwest in agricultural areas. Excess ATR can enter local aquatic environments through groundwater seepage and runoff, causing ATR concentrations to increase and placing non-target aquatic organisms, like crayfish, at risk of ATR exposure. Concentrations of ATR in local streams and rivers have been shown to reach over 80 ppb (μg/L). We have shown that acute exposures to ATR can cause long-term changes in response to both food and conspecific odors in crayfish. Knowing that ATR causes impairments of olfactory-mediated behaviors, we determined that ATR-exposures cause DNA damage to cells of the lateral antennule, in a dose-dependent manner. Thus, ATR exposure ultimately compromises the chemosensory abilities of crayfish. Currently, we are investigating if the hepatopancreas, which is responsible for filtering and detoxifying the body following xenobiotic exposure, can adequately remove ATR from the body. Understanding the effects of ATR and correlating these with accumulation and recovery from exposure to herbicides like ATR will allow us to assess the long-term effects of ATR on aquatic organisms. Because detoxification of xenobiotics is energetically demanding, responses to and recovery from ATR exposures may subsequently impact growth, development and reproduction.