The application of roadway deicing salts is increasing the salinity of freshwater systems around the world. Increased salinization from deicing salts such as NaCl, CaCl₂ and MgCl₂ can have direct, negative impacts on freshwater organisms at concentrations found in nature. Yet, our understanding of how these salts can indirectly impact freshwater organisms by altering important ecological interactions, such as those between host and parasite, are less understood. Using an amphibian (Rana sylvatica) -trematode (Echinostoma spp.) model, we examined whether exposure to NaCl, CaCl₂ or MgCl₂ 1) influences trematode mortality; 2) alters amphibian-trematode interactions; and 3) alters larval amphibian activity (behavior associated with parasite avoidance). We found that exposure to CaCl₂ greatly reduced trematode survival across all Cl^– concentrations (230, 500, 860 and 1000 mg Cl^– L^-1) while NaCl and MgCl₂ had no effect. Conversely, when both host and parasites were exposed to salts, NaCl, but not CaCl₂ or MgCl₂, increased infection. The lack of effect of CaCl₂ on infection was likely driven by CaCl₂ reducing trematode survival. Exposure to NaCl increased infection at 500 mg Cl^– L^-1, but not 230 or 860 mg Cl^– L^-1. However, unlike previous studies, this increase of infection was not due to salt exposure altering tadpole behavior. Overall, our results suggest that NaCl at environmentally relevant concentrations can negatively impact amphibian populations indirectly by increasing their susceptibility to parasites.