Global warming currently devastates corals by increasing ocean temperatures resorting to large-scale bleaching events. Coral diseases have risen alongside these in the past few decades, increasing mortality in tropical corals. As these continue, the response of corals in temperate systems are unknown. This research focuses on Astrangia poculata and how it will respond to increased temperature and disease exposure. This study examined colonies collected from Narragansett Bay located in Rhode Island to comparatively assess ambient (18 °C) versus elevated temperatures (26 °C) in the presence of disease (i.e. lipopolysaccharide isolated from E. coli O127:B8). This study assessed prophenoloxidase (PPO) and melanin via absorbance to determine A. poculata’s immune response. No differences were found in PPO between symbiotic state, treatments, or season. Melanin had higher concentrations in symbiotic compared to aposymbiotic coral (p≤0.05). This study is the first to report an immune response in A. poculata. Overall, we observed low melanization across treatments indicating potential susceptibility to disease. It is plausible that parameters such as the surface mucus layer and lectins from the complement pathway may contribute to protection where the upregulation of a melanin-synthesis pathway is not necessary. Although this study introduces the plausibility of disease susceptibility in A. poculata, future studies should investigate additional parameters such as lectins to further understand the entirety of innate immunity in this temperate species.