Meeting Abstract
The known xenoestrogen Bisphenol-A (BPA), has profound effects on planarian regeneration. Prior work in our lab has shown that BPA can depress and delay regeneration in a variety of flatworms at high doses and stimulate regeneration at very low doses. Since regeneration involves both proliferation and cell movement, we hypothesized that cytoskeleton may be one of the mechanisms by which endocrine disruptors are affecting regeneration in flatworms. In this work we compare the effects of Paclitaxel, a microtubule polymerization inhibitor, to BPA to determine if the regenerative phenotypes are similar.
