C elegans maneuvering strategies in heterogeneous environments


SOCIETY FOR INTEGRATIVE AND COMPARATIVE BIOLOGY
2021 VIRTUAL ANNUAL MEETING (VAM)
January 3 – Febuary 28, 2021

Meeting Abstract


74-8  Sat Jan 2  C. elegans maneuvering strategies in heterogeneous environments Diaz, K*; Chong, B; Ding, JL; Lu, H; Goldman, DI; Georgia Tech; Georgia Tech; Georgia Tech; Georgia Tech; Georgia Tech kelimar.diaz@gatech.edu

Slithering animals (e.g., snakes, nematodes) generate and propagate waves along their elongated body in order to traverse highly damped environments. In particular, the mm-long nematode worm C. elegans must execute complex behaviors in other to navigate its natural environment (e.g., rotting fruit) and overcome heterogeneities. Specifically, the worms are able to generate a time-dependent omega-like shape (known as omega turns) that allows them to achieve high in place rotation. Yet, few studies have focused on how the worm generates and controls body waves of curvature for self-propulsion in complex environments. To discover principles of nematode control, we conducted experiments in fluid filled PDMS multi-post array – a model heterogeneous environment. Surprisingly, the worm was not hindered by the heterogeneities when performing turns. Instead the worm was able to perform omega turns by wrapping its body around the obstacles. Performance was comparable to that of on the surface of homogeneous agar or buffer, where the worm was able to achieve high rotation while minimizing the swept area. Preliminary experiments with mechanosensing defective mutants (mec-4) suggest that worms do not need to sense their surroundings to perform turns in complex environments. Our results suggest omega turns are a robust strategy to turn and maneuver in a myriad of environments.

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