Honey bees (Apis mellifera) contribute to worldwide agricultural pollination. Since 2006, bee pollinators have experienced global declines, which may be linked to widespread agricultural use of neonicotinoid pesticides and a phenomenon known as colony collapse disorder (CCD). While CCD appears to be caused by many factors, neonicotinoid pesticides are indicated as a major factor in CCD. Neonicotinoids and pyrethroids differ in their chemical structure and strategies for application. We tested honey bees in acute exposure to two neonicotinoid (imidacloprid, acetamiprid) pesticides and one pyrethroid (deltamethrin) pesticide for sublethal motor coordination and stress responses. Motor and cellular stress responses (superoxide dismutase (SOD) activity) were measured after 4-h exposure to treatments. Control bees were fed 1.5 M sucrose and treatment groups were fed sublethal doses (1/5^th LD₅₀ to 1/500^th LD₅₀) of pesticides in 1.5 M sucrose. Doses were similar to those reported for the natural environment. After treatment, we evaluated the movement of the abdomen, legs, antennae, and proboscis extension reflex and calculated motor scores. Bees displayed impaired motor coordination at 1/5^th-1/10^th LD₅₀ when fed imidacloprid and at 1/5^th LD₅₀ when fed with acetamiprid. Deltamethrin did not impact motor coordination at the doses used in our study. Bees displayed increased SOD activity at 1/5^th-1/10^th LD₅₀ treatments of imidacloprid but no difference in SOD activity among acetamiprid or deltamethrin treatments. This suggests acetamiprid and deltamethrin are safer to honey bees than imidacloprid.