The postprandial increase in metabolism is well documented but can be highly variable between and within species depending on many factors. Larger meals typically cause a larger increase in metabolism. To further investigate this process, we studied the postprandial change in metabolic rate in Children’s pythons, Antaresia childrenii. We used closed-system respirometry to measure standard metabolic rate (SMR) as mass-specific VO2 (mL hr^-1 g^-1) at 29°C in fasted snakes (n=14) and following feeding of a rodent meal that was 10% or 25% body weight (n=7/group). Measurements were taken 1-3 days before and 0.5, 1, 2, 4, 6, 10, and 14 days post-feeding. Unexpectedly, SMR after feeding was not significantly different between the two meal sizes. Collectively, SMR rapidly increased within 0.5 days after feeding, peaked at one day post-feeding, slowly decreased, and was not significantly different from baseline by 10 days post-feeding. The mean maximum postprandial response was a 4-fold increase in SMR. Animals that feed infrequently tend to have a higher metabolic response to feeding than animals that feed more frequently, presumably due in part to mobilization of energy to grow the organs necessary for digestion and absorption of the meal. While our snakes were fasted for 2.5 weeks prior to the experiment, perhaps the duration of the fast was not sufficient to induce atrophy of the GI tract, thus less energy was required to mobilize the GI tract, even for a larger meal. Alternatively, it may be that these snakes expend energy to a similar extent, regardless of meal size. Future work will examine the fuel source (i.e., RER) associated with the postprandial response in this species.