Charles Darwin famously suggested that organisms can evolve nearly endless forms, however, biologists frequently identify the emergence of similar phenotypes in independent lineages experiencing similar selective pressures. Indeed, convergent evolution is pervasive in nature and evidence of convergence can be found across levels of biological organization. Foregut fermenting herbivores represent a classic example of convergent evolution. Colobine monkeys and ruminants have evolved similar foregut chambers that house microbial communities capable of fermenting the plant materials that make up their diets. Additionally, these species have convergently evolved a unique lysozyme expressed in the acidic compartment of their digestive tract that assists in the digestion of microbes coming from the foregut. This enzyme has convergently evolved similar protein structure and exhibits a functional optimal at low pH. Interestingly, herbivorous woodrats (Neotoma spp.) exhibit similar digestive morphologies, host dense and active foregut microbial communities, and express a foregut lysozyme. Here, we hypothesized that convergence in digestive morphologies may have resulted in the convergent evolution of lysozyme structure and function. We tested for evidence of molecular evolution using the PAML package. Additionally, we found that the foregut lysozyme of herbivorous woodrats exhibited a more acidic pH optima when compared to house mice, similar to the adaptations of foregut fermenting primates and ruminants. Overall, our results provide an additional example of how the evolution of similar diets and digestive strategies shape patterns of convergence across distantly related taxa.