Nature has harnessed nanotechnology to generate a variety of specialized smart materials which include antifouling, adhesive, hydrophobic, hydrodynamic, and antibiotic properties. A basic first step in understanding nature’s micro and nano-scale structures is the ability to visualize and image these very small yet complex structures easily and accurately. This can be a difficult endeavor. Electron microscopy is a common high-resolution imaging approach, with magnifications over 50,000X, yet electron microscopy can suffer from optical distortions and is typically limited to 2D images. In order to produce accurate 3D models of micro and nano-scale structures, I am developing an approach to combine electron microscopy with a 3D photogrammetry, which uses a collection of 2D images to produce a 3D reconstruction. Scanning election microscopy has the necessary resolution and is readily available. Data collection for photogrammetry is straight forward and also inexpensive. To investigate the use of photogrammetry to digitally reconstruct scanning electron microscopy images, I will focus on naturally occurring, complex, adhesive structures from gecko toe pads. These structures represent an amazing natural example of nanotechnology. Geckos (and other pad bearing lizards) use a wide variety of surfaces in the wild. Gaining a better understanding of their adhesive morphology is an exciting first step to better understanding how species are adapted to specific scansorial microhabitats. Investing adaptive patterns and biomechanics of the gecko adhesive system is also relevant for the production of synthetic gecko-like adhesives, currently an active area of biomimicry research.