Meeting Abstract

62.3  Tuesday, Jan. 6  The Role of Melatonin in the Cellular Processes in the suppression of Asexual Reproduction in Stenostomum virginianum (Platyhelminthes, Catenulida) STANTON, Daniel L*; SMITH III, Julian PS; Winthrop University; Winthrop University stantond2@winthrop.edu

Melatonin is a naturally occurring hormone responsible for diurnal activity in organisms ranging from single-celled algae to humans. We found that a 0.1mM concentration of exogenously applied melatonin suppressed asexual fissioning in Stenostomum virginianum (p<0.05). These results are consistent with data from triclad flatworms. At present, it is unclear how melatonin suppresses asexual reproduction. The suppression may be caused by a down-regulation of mitosis, an up-regulation of apoptosis, or by a combination of the two. We have examined the effect of melatonin on the mitotic rate of S. virginianum. Preliminary data show that exogenously applied melatonin does not appear to inhibit mitosis. We will present data on the effects of melatonin on apoptosis. Further research will allow for a better understanding of how melatonin affects the cellular cycle and influences biological activities in an organism. (Supported by funds from the Winthrop University Research Council)