In this symposium, we will present much of the work done as part of the Manakin Genomics Research Coordination Network (Manakin Genomics RCN, https://www.manakinsrcn.org). This RCN has brought together researchers from across disciplines to address the implications of sexual selection on evolution, ecology, behavior, and physiology using a clade of unique neotropical birds, the manakins. The manakins are a great example of sexual selection as nearly all of the 51 species are lek-breeding and highly sexually dimorphic. Males display elaborate vocal as well as visual courtship behaviors which are often highly acrobatic. In some cases, males exhibit cooperative displays. Males also exhibit unique neuroendocrine and physiological adaptations that underlie these behaviors. This symposium will highlight the remarkable genomic, behavioral, and physiological adaptations as a consequence of strong sexual selection pressures that are evident in manakins.